搅拌性能比较单轴和双轴搅拌机(中文6400字,英文4600字)
摘要
所涉及的粉末混合动力仍然是许多研究者感兴趣的话题，但是仍然落后的理论。该混频器大多仍设计，规模化的实证基础上。在许多行业，包括医药，大多数的混合是使用“翻滚混频器“。滚筒搅拌机是部分加载的材料和一些圈数旋转中空容器。一些常见的例子包括水平滚筒搅拌机，V型混合机，双锥混合机和bin搅拌机。在所有这些混频器而在同质化是快速旋转方向，由对流混合过程介导的，在水平（轴向）方向色散过程驱动，混合，往往是慢得多。在本论文中，我们探讨一种新的翻滚实验搅拌机，关于两个轴旋转：一个（翻滚动作）水平轴，中心对称轴（旋转运动）。进行详细研究的粉末混合性能和关键参数的影响，包括搅拌器的基本几何形状，速度，补平，挡板的存在，加载模式和旋转轴。在这项工作中对乙酰氨基酚用作活性药物成分和配方包含如常用Avicel和乳糖辅料。混合效率的特点，通过提取后，预先确定样品的转数来分析和近红外光谱技术，以确定成分的分布。结果显示过程变量包括粉末混合均匀性的旋转轴的重要性。
图形抽象
所涉及的粉末混合动力仍然是许多研究者感兴趣的话题，但是仍然落后的理论。该混频器大多仍设计，规模化的实证基础上。在许多行业，包括医药，大多数的混合是使用“翻滚混频器“。在所有这些混频器而在同质化是快速旋转方向，由对流混合过程介导的，在水平（轴向）方向色散过程驱动，混合，往往是慢得多。在本论文中，我们探讨一种新的翻滚实验搅拌机，关于两个轴旋转：一个（翻滚动作）水平轴，中心对称轴（旋转运动）。
关键词：粉末混合;凝聚力;搅拌机，混合机，相对标准偏差;近红外;对乙酰氨基酚
外文资料与中文翻译
Comparing mixing performance of uniaxial and biaxial bin blenders
Abstract
The dynamics involved in powder mixing remains a topic of interest for many researchers; however the theory still remains underdeveloped. Most of the mixers are still designed and scaled up on empirical basis. In many industries, including pharmaceutical, the majority of blending is performed using “tumbling mixers”. Tumbling mixers are hollow containers which are partially loaded with materials and rotated for some number of revolutions. Some common examples include horizontal drum mixers, v- blenders, double cone blenders and bin blenders. In all these mixers while homogenization in the direction of rotation is fast, mediated by a convective mixing process, mixing in the horizontal (axial) direction, driven by a dispersive process, is often much slower. In this paper, we experimentally investigate a new tumbling mixer that rotates with respect to two axes: a horizontal axis (tumbling motion), and a central symmetry axis (spinning motion). A detailed study is conducted on mixing performance of powders and the effect of critical fundamental parameters including blender geometry, speed, fill level, presence of baffles, loading pattern, and axis of rotation. In this work Acetaminophen is used as the active pharmaceutical ingredient and the formulation contains commonly used excipients such as Avicel and Lactose. The mixing efficiency is characterized by extracting samples after pre-determined number of revolutions, and analyzing them using Near Infrared Spectroscopy to determine compositional distribution. Results show the importance of process variables including the axis of rotation on homogeneity of powder blends.
Graphical abstract
The dynamics involved in powder mixing remains a topic of interest for many researchers; however the theory still remains underdeveloped. Most of the mixers are still designed and scaled up on empirical basis. In many industries, including pharmaceutical, the majority of blending is performed using “tumbling mixers”. In all these mixers while homogenization in the direction of rotation is fast, mediated by a convective mixing process, mixing in the horizontal (axial) direction, driven by a dispersive process, is often much slower. In this paper, we experimentally investigate a new tumbling mixer that rotates with respect to two axes: a horizontal axis (tumbling motion), and a central symmetry axis (spinning motion).
Keywords:Powder mixing ; Cohesion; Blender ; Mixer; Relative standard deviation; NIR; Acetaminophen |
