具有抗肿瘤活性的齐墩果酸连接糖的片段(任务书,开题报告,论文6000字)
摘 要
齐墩果酸在我国分布广泛，是中药中常用的一种药材，齐墩果酸具有很广泛的生物活性，比如止痛、利尿、抗肿瘤、抗菌和抗炎作用等等。
本文以齐墩果酸和葡萄糖为起始化合物合成齐墩果酸的衍生物，在糖基化之前，将葡萄糖转变成相应的糖供体，在TMSOTf（三氟甲磺酸三甲基硅醇酯）催化下与齐墩果酸乙酯C-3羟基进行糖苷化反应，得到目标产物3-O-[2,3,4,6-四苯甲酰基葡萄糖]-齐墩果酸乙酯。
关键词：齐墩果酸;化学合成;糖苷化
Abstract
Oleanolic acid distributed widely in our country,It is a kind of medicinal materials that is commonly used in traditional Chinese medicine，Oleanolic acid has a wide spectrum of biological effects,including various analgesic,diuretic,antitumor,antimicrobial and anti-inflammatory activities.
One oleanic acid derivative was synthesized with glucose and oleanic acid. Before the glycosylation of oleanic acid with the one saccharides,the saccharides were transferred into the corresponding glycosyl donors.Then the glycosylation of the saccharide donors with Oleanolic acid ethyl ester at 3-OH was catalyzed by trimethylsily1 trifluoromethanesulfonante(TMSOTF). 3-O-[2,3,4,6 - 4-benzoyl-glucose]-11-deoxy oleanic acid ethyl ester was obtained .
Key Words: oleanic acid;chemical synthesis;glycosylation;
目 录
摘 要…………………………………………………………………………………I
Abstract………………………………………………………………………………II
引 言…………………………………………………………………………………1
第一章 绪论……………………………………………………………………………2
第二章 实验材料和方法…………………………………………………………4
2.1 实验试剂…………………………………………………………………………4
2.2 实验仪器…………………………………………………………………………4
2.3 实验方法的建立…………………………………………………………………5
2.3.1 糖基受体合成………………………………………………………………5
2.3.2 糖基供体合成………………………………………………………………5
2.3.3 糖基供体和糖基受体的合成………………………………………………6
2.4 实验方法…………………………………………………………………………6
2.4.1 全苯甲酰化葡萄糖的制备…………………………………………………6
2.4.2 2,3,4,6-四-O-苯甲酰基葡萄糖的制备……………………………………7
2.4.3 2,3,4,6-四-O-苯甲酰化葡萄糖三氯乙酰亚胺酯的制备…………………8
参考文献…………………………………………………………………………………12
致 谢…………………………………………………………………………………14
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